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Sekarang jam 4:08 PTG di sini
Menyertai September 14, 2020
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Syor
Claudia L.
@ClaudiaLiberini
4.6
4.6
100%
100%
london,
united kingdom
100%
Pekerjaan Disiapkan
100%
Mengikut Bajet
100%
Tepat Pada Masa
14%
Kadar Upah Semula
Scientific/Technical Editor/CV&Resume Writer
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Portfolio
Portfolio
DATA ANALYSIS AND GRAPHICSA
Introduction
Scientific Abstract
DATA ANALYSIS AND GRAPHICSA
Introduction
Scientific Abstract
Ulasan
Perubahan disimpan
Menunjukkan 1 - 5 daripada 6 ulasan
$300.00 USD
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Proofreading
Technical Writing
Editing
Research Writing
Article Rewriting
+1 lagi
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•
€200.00 EUR
Editing
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$150.00 CAD
Scientific Research
Article Writing
Research Writing
Biology
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€220.00 EUR
Graphic Design
Copywriting
Editing
Research Writing
Resumes
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Pendidikan
Postdoctoral Research Associate
(1 tahun)
Postdoctoral Research Fellow
(2 tahun)
PhD in Integrative Molecular Medicine
(4 tahun)
Penerbitan
Early life overnutrition impairs plasticity of non-neuronal brainstem cells
Int J Obes (Lond) . 2020 Sep 30. doi: 10.1038/s41366-020-00658-5
The prevalence of adolescent obesity has increased dramatically, becoming a serious public health concern. While previous evidence suggests that in utero- and early postnatal overnutrition increases adult-onset obesity risk, the neurobiological mechanisms underlying this outcome are not well understood.
Amylin receptor components and the leptin receptor are co-expressed
Eur J Neurosci . 2016 Mar;43(5):653-61. doi: 10.1111/ejn.13163. Epub 2016 Feb 5
Single AP cells expressed both AMY and LepRb, which formed a population of first-order neurons that presumably can be directly activated by amylin and, at least in part, also by leptin.
The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats
Mol Metab . 2016 Jul 5;5(10):834-843. doi: 10.1016/j.molmet.2016.06.015. eCollection 2016 Oct.
Adult neurogenesis in the subgranular zone and subventricular zone is generally accepted, but its existence in other brain areas is still controversial. Circumventricular organs, such as the area postrema (AP) have recently been described as potential neurogenic niches in the adult brain.
Brainstem GLP-1 signalling contributes to cancer anorexia-cachexia syndrome in the rat.
Neuropharmacology . 2018 Mar 15;131:282-290. doi: 10.1016/j.neuropharm.2017.12.024
The cancer anorexia-cachexia syndrome (CACS) is a frequent and severe condition in cancer patients. Currently, no pharmacological treatment is approved for the therapy of CACS. Centrally, glucagon-like peptide-1 (GLP-1) is expressed in the nucleus tractus solitarii (NTS) and is implicated in malaise, nausea and food aversion.
A vitamin B12 conjugate of exendin-4 improves glucose tolerance
Diabetes Obes Metab . 2018 May;20(5):1223-1234
While pharmacological glucagon-like peptide-1 receptor (GLP-1R) agonists are FDA-approved for treating type 2 diabetes mellitus (T2DM) and obesity, a major side effect is nausea/malaise. We recently developed a conjugate of vitamin B12 (B12) bound to the GLP-1R agonist exendin-4 (Ex4), which displays enhanced proteolytic stability and retention of GLP-1R agonism. Here, we evaluate whether the conjugate (B12-Ex4) can improve glucose tolerance without producing anorexia and malaise.
Combined Amylin/GLP-1 pharmacotherapy to promote and sustain long-lasting weight loss.
Scientific Reports, volume 9, Article number: 8447 (2019)
A growing appreciation of the overlapping neuroendocrine mechanisms controlling energy balance has highlighted combination therapies as a promising strategy to enhance sustained weight loss. Here, we investigated whether amylin- and glucagon-like-peptide-1 (GLP-1)-based combination therapies produce greater food intake- and body weight-suppressive effects compared to monotherapies in both lean and diet-induced obese (DIO) rats.
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